André Woodson threw for a 51-yard touchdown on Kentucky's first snap of the season, as the Wildcats rout Eastern Kentucky, 50–10.[3] Kentucky scored five touchdowns on their first eight drives, and punted only once, in the fourth quarter. Rafael Little had 135 yards on the ground for Kentucky.[3]
Kentucky had 266 yards and six touchdowns on the ground, but Kentucky's porous run defense was gashed for 324 yards on the ground by the Golden Flashes.[4] Woodson looked out of sync until he hit Keenan Burton for a fifty-one yard score in the third quarter. Tony Dixon, André Woodson, Alfonso Smith, and Derrick Locke all had one rushing touchdown for Kentucky, where John Conner had two.[4]
Kent State struck first on a fake field goal, ran six yards for a touchdown by holder Leneric Muldrow. Conner ran in from five yards out, and Woodson fired back with a 33-yard touchdown pass to give the Wildcats a 14–7 lead.[4] The Golden Flashes Eugene Jarvis scored on a ten-yard run up the middle, but John Conner and Tony Dixon ran in, and André Woodson hit Keenan Burton to the right for 51 yards and a touchdown. Kent State, down 14–35 answered with a Julian Edelman pass to Eugene Jarvis for a 22-yard touchdown, but Woodson, Alfonso Smith, and Derrick Locke ran in for touchdowns of 1, 12, and 67 yards respectively.[4]
With 28 seconds left, André Woodson threw a 57-yard touchdown pass to Stevie Johnson to knock off #9 Louisville, the first time the Wildcats had beaten a top ten team in thirty years.[5] Woodson finished 30 of 44 for 275 yds and four touchdowns.[5] Woodson also did not throw an interception, and he ended the game with 257 passes without an interception. This became a new SEC record, breaking David Greene's record and falling fourteen attempts short of Trent Dilfer's all-time mark.[5]
Placekicker Lones Seiber started the scoring for the Wildcats with a 36-yard field goal, and Woodson followed later with a five-yard touchdown strike, with another Seiber kick, to make the lead 13–0 in favor of Kentucky.[5] Louisville Senior QuarterbackBrian Brohm found Anthony Allen for an eight-yard touchdown. Rafael Little ran up the middle for a ten-yard score in the second quarter, but Seiber missed the PAT, resulting in a 19–7 Kentucky lead. Brian Brohm passed to Harry Douglas for a TD, and Louisville added a ten-yard touchdown run from Anthony Allen to pull in front 21–19.[5]
Opening the second-half scoring, Woodson threw a seven-yard touchdown pass but on the ensuing kickoff lightning struck for the Cardinals in the form of Trent Guy's 100 yard kickoff return. Once again, Kentucky answered with a Woodson pass to Jacob Tamme.[5] Brohm then began an 84-yard drive that ended in Anthony Allen's 2-yard touchdown run and a Cardinal lead. Brohm would've been sacked for a loss on the drive, but a fifteen-yard personal foul penalty on cornerback Trevard Lindley gave the Cardinals room to operate as well as a fresh set of downs.[5] Despite Brohm's heroics, they were topped by Woodson's 57-yard touchdown hookup to wideout Steve Johnson to beat the Cardinals for the first time in Kentucky's last five tries.[5] This was the first time Woodson had gotten a win against Brohm, Woodson's rival dating back to their high schools, separated by only 45 miles.[6]
Quarterback Andre Woodson set a new NCAA record with 325 consecutive pass attempts without an interception. His 40 touchdown passes set a new SEC record, and his 81 career touchdown passes set a new school record.